Clinical Trial: Genetics of Cytochrome CYP2D6 and Effects of Codeine and Tramadol on Postoperative Pain Management
Study Status: COMPLETED
Recruit Status: COMPLETED
Condition: Post-operative Pain
Study Type: OBSERVATIONAL
Official Title: A Genetic Survey of Cytochrome P450 2D6 Genotypes by Nanopore DNA Sequencing and Clinical Response to Codeine and Tramadol in Postoperative Pain Management
Brief Summary:
Codeine is one of the most commonly prescribed opioids in the world.The speed at which our liver metabolizes codeine into morphine depends on an important protein called cytochrome P450 2D6 (CYP2D6).Many people across the world have different CYP2D6 metabolizing speeds.Codeine provides inadequate pain management to those who have slow-metabolizing CYP2D6.In contrast, codeine can be life-threatening to those who have rapidly-metabolizing CYP2D6 because of the abruptly high dose of morphine.By analyzing specific…
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