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The oncometabolite R-2-hydroxyglutarate inhibits microglial activation via the FTO/NF-?B pathway

Abstract: Mutations in isocitrate dehydrogenase 1 (mIDH1) generate the oncometabolite (R)-2-hydroxyglutarate (R-2HG), which promotes tumorigenesis by inhibiting…

Date: 2025-11-27

Time series forecasting of red blood cell demand in hematology patients using SARIMA and exponential smoothing models: a retrospective analysis in a Chinese tertiary hospital

Abstract: Red blood cells (RBCs) infusion is very important for the treatment of hematology patients, but how to maintain a balanced state between the supply and demand of RBCs is…

Date: 2025-11-27

Associations between gut microbiota and immune status in untreated B-cell lymphoma patients

Abstract: Emerging evidence links gut microbiota to tumorigenesis via immune modulation, though subtype-specific microbial signatures in B-cell lymphomas remain unclear. This…

Date: 2025-11-27

Identification and validation of mitochondrial and programmed cell death-related prognostic markers in pediatric acute myeloid leukemia

Abstract: Pediatric acute myeloid leukemia (AML) is characterized by poor prognosis and low survival rates following recurrence. While mitochondria and programmed cell death (PCD)…

Date: 2025-11-27

A novel CTLA-4 deletion variant in a child with refractory autoimmune hemolytic anemia: molecular and functional characterization

Abstract: As a critical immune checkpoint, cytotoxic T-lymphocyte-associated protein 4( CTLA-4 )deficiency is a well-established cause of inborn errors of immunity. This study…

Date: 2025-11-27

CldU sensitizes BRCA2 reverse-mutated cells to PARP inhibitors

Abstract: PARP inhibitors are widely used class of drugs for the treatment of homologous recombination deficient cancers, including BRCA mutated ones. These drugs led to…

Date: 2025-11-27

Allogeneic hematopoietic stem cell transplantation for mixed-phenotype acute leukemia: a single-center study

Abstract: Mixed-phenotype acute leukemia (MPAL) is a rare subtype of acute leukemia with unfavorable outcome. There is no established optimal therapy regime. We conducted a…

Date: 2025-11-27

Global burden of anemia attributed to chronic kidney disease: prevalence, years lived with disability, and predictions to 2035 (Global burden of disease 2021)

Abstract: As a common complication of chronic kidney disease (CKD), anemia is associated with increased mortality and reduced quality of life. Despite its severe impact, there is…

Date: 2025-11-27

Multi-antigen MVA-vectored SARS-CoV-2 vaccine, GEO-CM04S1, induces cross-protective immune responses to ancestral and Omicron variants

Abstract: The design focus of the first-generation COVID-19 vaccines was on the use of the SARS-CoV-2 spike (S) protein as the primary vaccine immunogen to induce high levels of…

Date: 2025-11-27

Promiscuous class II-binding SARS-CoV-2-nuc derived vaccine-peptide induced extensive conventional, innate and unconventional T cell responses

Abstract: We describe the T-cell response of two healthy SARS-CoV-2-unexposed volunteers to a SARS-CoV-2 nucleoprotein-derived vaccine peptide predicted to promiscuously bind…

Date: 2025-11-27