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Sequencing-informed, patient-specific droplet digital PCR assays for circulating tumor DNA monitoring in recurrent or metastatic head and neck cancer: a pilot study

Abstract: In recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), early identification of treatment response remains challenging because imaging may be…

Date: 2026-10-30

Gut microbiota dysbiosis and altered short-chain fatty acid biosynthetic pathways in Chinese children with obesity and nonalcoholic fatty liver disease

Abstract: Nonalcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), is the most prevalent chronic liver…

Date: 2026-10-30

Development and psychometric evaluation of a pre-sarcopenia risk assessment scale for sedentary young adults with type 2 diabetes mellitus

Abstract: The aim of this study was to develop a self-reported risk-assessment scale for pre-sarcopenia-related behavioral and functional risk in sedentary young adults with type…

Date: 2026-10-30

Utilizing AI for decision support in severe asthma biological treatment

Abstract: Severe asthma remains a major clinical challenge because of disease heterogeneity and variable response to biologic therapies. Despite the availability of clinical…

Date: 2026-10-30

Four-dimensional left atrial quantification for predicting major adverse cardiovascular events in patients with uremia: an interpretable LASSO-logistic model

Abstract: This study aimed to develop a machine learning model using four-dimensional left atrial quantification (4D-LAQ) parameters to the risk of major adverse cardiovascular…

Date: 2026-10-30

Nonlinear associations between physical activity, sleep quality, and psychological distress in university students: a cross-sectional interpretable machine learning study

Abstract: Physical activity and sleep disturbance may have nonlinear, interrelated associations with psychological distress. Objective: To develop an internally validated…

Date: 2026-10-30

Prediction of high-flow nasal cannula failure in COVID-19 acute hypoxemic respiratory failure using combined clinical and metabolomic data: a machine learning study

Abstract: High-flow nasal cannula (HFNC) is widely used as first-line non-invasive respiratory support in acute hypoxemic respiratory failure (AHRF), particularly during the…

Date: 2026-10-30

Tissue factor-associated neutrophil extracellular traps in dermatomyositis: procoagulant activity and endothelial activation in vitro

Abstract: Dermatomyositis (DM) is an immune-mediated myopathy characterized by inflammatory and vascular manifestations and variable systemic involvement; however, the interplay…

Date: 2026-10-30

Lesion-directed quantitative EEG after reperfusion therapy is associated with malignant cerebral edema and functional outcomes in acute ischemic stroke: a prospective exploratory cohort study

Abstract: Ischemic stroke causes electrophysiological slowing within minutes which may precede detectable structural changes, making electroencephalography (EEG) a sensitive…

Date: 2026-10-30

Efficacy and safety of low-power (20?W) catheter ablation for typical atrioventricular nodal reentrant tachycardia: a prospective multicenter study

Abstract: Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia. Although catheter ablation is the definitive treatment,…

Date: 2026-10-30