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First received: January 24, 2026

Clinical Trial: Metformin vs Inositol vs Diet vs Combination Therapy in PCOS

Study Status: COMPLETED

Recruit Status: COMPLETED

Condition: Polycystic Ovary Syndrome

Study Type: INTERVENTIONAL


Official Title: Comparative Effectiveness of Metformin, Inositol, Dietary Restriction, and Combination Therapy in Polycystic Ovary Syndrome: A 12-Week Prospective Randomized Study

Brief Summary: Polycystic ovary syndrome (PCOS) is a common condition that can cause irregular periods, excess male-type hormones, weight gain, and insulin resistance.This study will compare four commonly used approaches for PCOS management: metformin, inositol, a calorie-restricted diet, and a combination of all three.A total of 192 women aged 18-35 years with PCOS (diagnosed using Rotterdam criteria) will be randomly assigned to one of four groups for 12 weeks: (A) metformin, (B) myo-inositol plus D-chiro-inositol, (C)…

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