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First received: December 24, 2025

Clinical Trial: Licorice Extract Gel Versus Diode Laser for Physiologic Gingival Pigmentation

Study Status: COMPLETED

Recruit Status: COMPLETED

Condition: Gingival Hyperpigmentation

Study Type: INTERVENTIONAL


Official Title: A Comparative Evaluation of the Effectiveness of Topical Licorice Extract Gel and Diode Laser 445 nm on Physiologic Gingival Pigmentation

Brief Summary: This randomized controlled clinical trial aims to compare the effectiveness of topical licorice extract gel and diode laser (445 nm) in the treatment of physiologic gingival pigmentation.Twenty-four adult patients presenting with physiologic melanin pigmentation in the anterior esthetic zone of the maxillary or mandibular gingiva will be randomly allocated into two equal groups.One group will be treated with diode laser therapy, while the other group will receive topical licorice extract gel.Clinical outcomes will…

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