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Course: Porokeratosis

CME Credits: 1.00

Released: 2022-12-14

A woman in her 20s presented with multiple hyperpigmented plaques involving the face, trunk, and bilateral upper and lower extremities. On examination, lesions had well-defined, threadlike borders and central atrophy (). One of the plaques on the left foot measured 4?×-4 cm and extended to involve the great toe, which was followed by partial anonychia. Dermoscopy results were notable for irregular, double-marginated, white borders with central brown dots and globules. Histopathology results revealed a keratin-filled epidermal invagination with an angulated, parakeratotic tier (cornoid lamella), the focal absence of a granular layer, and the presence of dyskeratotic cells in the underlying epidermis. Based on these findings, a diagnosis of disseminated superficial porokeratosis (DSP) was made. Routine laboratory studies and infectious serology results were unremarkable, and chest and pelvic imaging results yielded no abnormalities. Treatment with oral acitretin was initiated at a dose of 25 mg daily, and the lesions showed substantial improvement at 6 months.


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