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Course: Pigmented Squamous Cell Carcinoma In Situ of the Eyelid

CME Credits: 1.00

Released: 2024-01-18

A healthy 61-year-old female patient presented for evaluation of a medial canthal pigmented lesion that had been growing larger for the past 2 years. She denied itching, bleeding, or pain. A dermatologist had noted brown and red papules on her chest thought to be seborrheic keratoses, benign nevi, and cherry angiomas. Examination revealed a flat 3 × 3-mm hyperpigmented lesion with irregular margins (Figure, A). Histopathology from a 2-mm punch biopsy demonstrated atypical keratinocytes spanning the entire thickness of the epidermis without invasion of the dermis, leading to a diagnosis of pigmented squamous cell carcinoma in situ (Figure, B). Pigmented squamous cell carcinoma is a rare variant of squamous cell carcinoma. It has been described on the face, conjunctiva, esophagus, and oral and genital mucosa.1- 3 The patient is currently planned for Mohs surgery and oculoplastic reconstruction.


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