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Course: Real-Time Magnetic Resonance Imaging During Convective Gene Therapy Perfusion of the Brain

CME Credits: 1.00

Released: 2024-01-10

Direct convection-enhanced delivery (CED) of viral vectors carrying therapeutic genes is being used for gene therapy in a variety of neurologic diseases, including neurodegenerative, neurotransmitter, epileptic, metabolic, and white matter disorders.1 The bulk flow properties of CED permit the reliable, safe, and homogeneous distribution of viral vectors for gene therapy across the blood-brain barrier. Convective perfusion, via infusion cannulae placed to targeted brain structures, can be noninvasively monitored in real time using magnetic resonance imaging (MRI) of a coinfused surrogate tracer (gadolinium-diethylenetriamine pentaacetate)1 to accurately define distribution of infused viral vectors and transgene expression at the perfused brain region.1,2


To identify the key insights or developments described in this article


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