why choose us

Course: Numerous Peripheral Retinal Yellow Flecks in an Adult Woman

CME Credits: 1.00

Released: 2022-09-15

A healthy 24-year-old woman born from a nonconsanguineous marriage presented with progressively blurred vision in both eyes. Further questioning revealed no history of night blindness, although she disclosed the presence of delayed dark adaptation. Best-corrected visual acuity was 20/40 OD and 20/25 OS with mild anisometropic amblyopia. Anterior-segment examination was unremarkable. Fundus examination revealed the presence of bilateral, numerous, deep yellow flecks (). A diagnosis of fundus albipunctatus (FA) was made, and a full-field electroretinography (ERG) was performed showing Riggs-type ERG with markedly reduced scotopic responses and loss of both a and b waves. FA is a form of hereditary night blindness with autosomal-recessive inheritance. FA is the result of a biallelic variation in the gene coding for retinol dehydrogenase 5, which causes a dysfunction of 11-cis retinol dehydrogenase., Rod damage may be progressive and not stationary; more importantly, there may be associated cone dystrophy, which compromises the visual prognosis.,


To identify the key insights or developments described in this article


View Full Course