Course: Punctate Diffuse Cortex Signals in Creutzfeldt-Jakob Disease
CME Credits: 1.00
Released: 2024-01-02
Patient 1 is a 54-year-old female who presented with sleep disturbances, including insomnia, rapid eye movement sleep behavior disorder, and laryngeal stridor 3 months prior to admission. As her condition progressed, she began to exhibit unsteady walking, slurred speech, and mild cognitive impairment. The patient had no serious personal or family medical history. Neurological examination revealed cognitive impairment; superficial hypoesthesia in the right face, arm, and leg; increased muscle tone; and coordination and balance dysfunction. Brain magnetic resonance imaging (MRI) revealed multiple punctate diffuse high signals on diffusion-weighted imaging (DWI), observed in the cortex and thalamus (Figure 1). Investigations focused on infectious, toxic, inherited metabolic, and central nervous system lymphoma etiologies but yielded no significant findings.
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