Course: Newborn Girl Presenting With Erythema and Blisters
CME Credits: 1.00
Released: 2023-12-13
A full-term girl was born with multiple areas of erythema, vesicles, and bullae on the face, trunk, and extremities. Her vital signs, including temperature, respiration, and heart rate, were within normal ranges. One month later, she returned due to skin eruptions that continued to wax and wane. Physical examination revealed multiple round or irregularly shaped erythematous macules and slightly scaly plaques of various sizes on the face, trunk, and extremities. Bullous and vesicular lesions were observed on the thighs, with scattered facial erosions. Mucous membranes were not found to be affected. She was born to healthy, nonconsanguineous parents. Growth and development were normal for her age and sex. The patient’s family medical history was unremarkable. A skin-punch biopsy and direct immunofluorescence (DIF) assays taken from 1 of the erythematous scaly plaques were performed for further analysis. At the 3-year follow-up, it was found that the vesicles and bullae began to decrease in number when she was 6 months old but intermittently returned after 1 year of age. The number of annular hyperkeratotic plaques had increased (Figure 1A). Thickened, brown, corrugated plaques developed over the neck, armpits, wrists, and ankles, along with palmoplantar hyperkeratosis.
Educational Objective
Based on this clinical scenario and the accompanying image, understand how to arrive at a correct diagnosis.
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