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Course: A Curious Case of Intermittent Negative Deflections Preceding the QRS Complexes

CME Credits: 1.00

Released: 2023-10-23

A patient in their 60s with a history of rectal carcinoma underwent chemotherapy (fluorouracil) followed by rectal resection with ileostomy, which was later closed. Subsequently, due to mechanical ileus, the patient underwent subtotal colectomy. Due to progression of abdominal wall metastases, the patient received FOLFIRINOX (fluorouracil, leucovorin, irinotecan, and oxaliplatin) treatment, which was interrupted because of new apparent abnormal Q waves in the electrocardiogram (ECG) (, A). Apart from severe hypomagnesemia (serum magnesium level, 1.12 mg/dL; normal value, >1.58 mg/dL; to convert to mmol/L, multiply by 0.4114), there were no abnormal laboratory findings. The patient had no anginal symptoms or palpitations. Echocardiography showed normal left ventricular function (left ventricular ejection fraction, 70%) without wall motion abnormalities.


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