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Course: Clinical Management of Neuropathic Itch

CME Credits: 1.00

Released: 2023-09-20

Neuropathic itch refers to disorders characterized by chronic itching caused by dysfunction or damage to pruriceptors, nerves involved in itch transmission. In these conditions, itch is not triggered by external stimuli (eg, irritants or allergens), but rather arises spontaneously. Neuropathic itch can occur through nerve damage from mechanical, metabolic, inflammatory, or cytopathic injury. It is often accompanied by neural hypersensitivity manifesting as alloknesis (itch) or dysesthesia (eg, burning, stinging) in response to innocuous mechanical stimuli. Although pruritus arising from nerve damage in the central nervous system can occur, most common itch conditions arise peripherally. Further, although many generalized itch conditions exhibit neuropathic qualities (eg, prurigo nodularis, diabetic itch), the extent to which neuropathy alone is the primary driver remains controversial. Thus, we will focus on the mechanisms underlying and therapeutic management of peripheral sensory itch conditions in this review.


To identify the key insights or developments described in this article


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