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Course: Favre-Racouchot Syndrome

CME Credits: 1.00

Released: 2024-01-31

A 69-year-old male Chinese farmer presented with bilateral facial lesions that had gradually worsened during the previous 20 years. He had a history of smoking (>10 cigarettes every day) for at least 30 years, but was otherwise healthy and denied any exposure to radiation, toxins, or chemicals. On physical examination, multiple solitary open black comedones were located bilaterally on the malar cheeks and temples. In addition, yellowish, smooth-surfaced papulonodular lesions were present in close association with the comedones. These lesions were clustered on both sides of the malar and periorbital areas, giving a cobblestone appearance. Deep wrinkles and multiple solar lentigines were also present (Figure). Histopathological examination revealed severe solar elastosis in the superficial dermis, a dilated follicular infundibulum filled with cornified materials, and an adjacent thin-walled infundibular cyst. Based on these clinical and histopathological findings, a diagnosis of Favre-Racouchot syndrome (FRS) was established. Avoidance of sun exposure and discontinuation of smoking were advised and tretinoin cream, 0.05%, was prescribed for topical use at night. The lesions improved slightly when assessed at a 1-month follow-up. The patient declined any other treatments.


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