Course: Cutaneous Angiosarcoma
CME Credits: 1.00
Released: 2023-01-18
A Latin American woman in her 50s with a history of breast cancer status post lumpectomy and adjuvant radiation therapy presented with a 3-month history of a right neck nodule and purpuric rash on her right cheek. The growing nodule and rash were thought to be lymphadenopathy by an outside clinician before she presented to our dermatology clinic 3 months later. She endorsed progressive swelling around the right eye but denied systemic symptoms. Physical examination revealed a large, purpuric plaque involving most of her right face with associated periorbital swelling but without ulceration. Two punch biopsy specimens demonstrated a proliferation of vessels lined by CD31+, D2,40+, MYC+, and HHV8? atypical crowded endothelial cells, which was consistent with angiosarcoma. Imaging results demonstrated tumor involvement of the orbit, fascia, and platysmas and suggested pulmonary, pleural, osseous, and nodal metastases.
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