Research Article: A Case of Sotos Syndrome in a Preterm Infant with Severe Bronchopulmonary Dysplasia and Congenital Heart Disease
Abstract:
Sotos syndrome is an autosomal dominant genetic disorder caused by mutations in the NSD1 gene. In this study, we report a case of Sotos syndrome in a preterm infant. The main clinical manifestations were severe bronchopulmonary dysplasia, congenital heart disease, difficulty feeding, and characteristic facial appearance. The gene mutation was located at 177251854 on chromosome 5, and identified as a shear mutation, c.4765+1 G > A, which is a new mutation. The patient recovered well after symptomatic treatment. To the best of our knowledge, this is the first case of a preterm infant in whom a novel c.4765+1 G > A mutation in the NSD1 gene was identified. When premature infants present with abnormally severe bronchopulmonary dysplasia, feeding difficulties, and other congenital anomalies, Sotos syndrome should be considered.
Introduction:
Sotos syndrome (SoS) is a childhood overgrowth condition, first described in 1964 by Sotos et al. [1]. It is characterized by three cardinal features: a distinctive facial appearance (including a broad and prominent forehead with a dolichocephalic head shape, sparse frontotemporal hair, down-slanting palpebral fissures, a long and narrow face, and a long chin), learning disability, and overgrowth. Neonates with SoS may also have jaundice, hypotonia, and poor feeding [2]. To date, and to the extent of our…
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