Research Article: Treatment of High-Risk Neuroblastoma
Abstract:
High-risk neuroblastoma is a highly aggressive solid tumor that most commonly presents in early childhood. Advances in treatment through decades of clinical trials and research have led to improved outcomes. This review provides an overview of the current state of treatment for high-risk neuroblastoma.
Introduction:
Neuroblastoma is the most frequent cancer in children less than one year old, and the most common solid tumor occurring outside of the central nervous system in all age groups [1]. Neuroblastoma displays a broad spectrum of clinical behavior and includes the following three risk groups: low, medium, and high. About half of patients with neuroblastoma are classified as having high-risk disease, by a combination of factors including age at diagnosis, extent of disease, histological findings, and cytogenetic…
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