Research Article: Perforating Gout: Expanding the Differential for Transepidermal Elimination
Abstract:
Perforating dermatoses are dermatologic disorders with transepidermal elimination (TE) of dermal substances. While TE is typically associated with collagen and elastin, it can also occur as a secondary event in other processes, and it is important to keep a broad differential. We present a case of perforating tophaceous gout, which underscores the need for a thoughtful approach to perforating disorders. An updated review of recent literature is also presented.
Introduction:
Perforating dermatoses are a group of dermatologic disorders characterized by transepidermal elimination (TE) of dermal substances, including collagen, elastin, and other connective tissue components [1]. Less commonly, perforation can be due to the elimination of other materials, including calcium, mucin, foreign bodies, and even cellular material such as melanocytes. Granulomatous inflammation can also lead to perforation, examples of which include granuloma annulare, sarcoid nodules, rheumatoid nodules, and…
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