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Research Article: Multisystemic Inflammatory Syndrome Temporally Associated with COVID-19 in a Regional Pediatric Hospital from México

Date Published: 2023-05-26

Abstract:
Multisystemic inflammatory syndrome (MIS-C) is an inflammatory condition temporally associated with COVID-19 in children; nevertheless, the clinical and immunologic spectrum of MIS-C is heterogeneous, and its long-term effects are unknown. During the period of August 2020 to December 2021, a total of 52 MIS-C cases were confirmed in pediatric patients from the Hospital del Niño DIF Hidalgo, diagnosed using criteria from the World Health Organization. All patients had serologic IgG confirmation of SARS-CoV2, the mean age of the patients was 7 years, and 94% of the patients did not have a previous underlying disease. In addition to the presentation of lymphopenia, neutropenia, and thrombocytopenia, elevations in D-dimer and ferritin levels were observed in all patients. There was clinical improvement with intravenous gamma globulin and corticosteroid treatment.

Introduction:
On 25 April 2020, the National Health Service of the United Kingdom issued a warning about a multisystemic inflammatory syndrome in children (MIS-C) that was temporally associated with SARS-CoV-2, with clinical characteristics similar to those found in Kawasaki disease (KD), toxic shock syndrome, hemophagocytic lymphohistiocytosis, and macrophage activation syndrome [1,2]. The first reports in 2020 compared MIS-C symptoms to those of KD (with fever mucocutaneous features and cardiac sequelae), but the recent…

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