Research Article: SNAP25 is a potential target for early stage Alzheimer’s disease and Parkinson’s disease
Abstract:
Alzheimer’s disease (AD) and Parkinson’s disease (PD), two common irreversible neurodegenerative diseases, share similar early stage syndromes, such as olfaction dysfunction. Yet, the potential comorbidity mechanism of AD and PD was not fully elucidated.
Introduction:
Neurodegenerative diseases (NDDs) are common irreversible diseases, which are the leading causes of disability in people over 65 years [1, 2]. NDDs mainly include Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), and multiple sclerosis (MS). Among them, AD and PD have higher incidences and are usually sporadic in most cases. The characteristic pathological hallmarks of AD and PD are progressive loss of neurons and accumulation of pathological…
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