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Research Article: Using a developed co-culture device to evaluate the proliferation of bone marrow stem cells by stimulation with platelet-rich plasma and electromagnetic field

Date Published: 2023-12-05

Abstract:
Bone marrow stem cell can differentiate to osteoblast by growth factors, pulsed low-intensity ultrasound and electric magnetic field. In the research, bone marrow stem cells were cultured; bone marrow stem cells in culture can be stimulated by platelet-rich plasma and electric field.

Introduction:
Surgeries for spinal arthrodesis or long bone nonunion often require bone grafts, which can come from autologous, allogeneic, or artificial sources. However, autologous bone grafting is limited by available bone mass and significant donor morbidity [1, 2], while allograft bone has limited osteoinductive properties, a high rate of false fusion, and a risk of disease transmission [3,4,5]. Although artificial bone substitutes such as Calcium Sulfate, Calcium Phosphate, or Hydroxyapatite are also used in spinal fusion…

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