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Research Article: Disease aggravation following surgery in a rare patient suspected to Fibrodysplasia (Myositis) ossificans progressiva: a case report

Date Published: 2023-12-04

Abstract:
Fibrodysplasia ossificans progressiva (FOP) as a rare and heritable disorder with the infrequent genetic transmission of the condition is a catastrophic disorder of heterotopic ossification (HO) and a cause of extraskeletal bone formation in humans. Given the lack of effective treatment for this disease, the important point is to avoid aggravating factors such as bone biopsy, surgery, and intramuscular injection.

Introduction:
Fibrodysplasia ossificans progressiva (FOP), as a rare, heritable and severely disabling genetic condition of connective tissue and progressive heterotopic ossification (HO), is the most catastrophic disorder of HO and a cause of extraskeletal bone formation in humans [1]. According to the literature, the worldwide prevalence of this disorder is approximately 1/2,000,000. There is no difference in the FOP distribution based on ethnic, racial, gender, or geographic factors [2]. The FOP disease was described for the…

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