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Research Article: Elevated remnant cholesterol and atherosclerotic cardiovascular disease in diabetes: a population-based prospective cohort study

Date Published: 2023-09-30

Abstract:
Elevated remnant cholesterol is observationally and causally associated with increased risk of atherosclerotic cardiovascular disease (ASCVD) in the general population. This association is not well studied in individuals with diabetes, who are often included in clinical trials of remnant cholesterol-lowering therapy. We tested the hypothesis that elevated remnant cholesterol is associated with increased risk of ASCVD in individuals with diabetes. We also explored the fraction of excess risk conferred by diabetes which can be explained by elevated remnant cholesterol.

Introduction:
Diabetes will affect more than 500 million people worldwide during the 2020s [1], challenging current strategies for prevention of atherosclerotic cardiovascular disease (ASCVD). In this context, elevated remnant cholesterol, including cholesterol carried in VLDL and chylomicron remnants, is emerging as a causal risk factor for ASCVD [2, 3], in addition to elevated LDL-cholesterol. Remnant cholesterol is highly correlated with plasma triglycerides as they are both carried in triglyceride-rich lipoproteins, but…

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