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Research Article: Interleukin- (CT) Gene Polymorphism in Association with Asthma Severity

Date Published: 2023-11-21

Abstract:
Asthma is a common chronic inflammatory disease affecting more than million people worldwide and could develop at any age; however, the first asthma symptoms mostly appear in the childhood. Episodes of bronchial hyper-responsiveness and reversible airway obstruction are the characteristic hallmarks of asthma. The main causes of asthma are not known; however, several factors trigger the pathogenesis cascade of asthma, which include environmental triggers such as pollutants, tobacco smoking, allergens, viral and bacterial infection, and genetic variations., The interaction between all these underlying risk factors increases the possibility of asthma presentation and even could determine the disease severity and control. The pathogenesis of asthma is complex, and several immune cells and biomarkers are involved including T-lymphocyte, mast cells and eosinophils, and cytokines such as IL-, IL-, and IL- plus the immunoglobulin-E (IgE).,

Introduction:
Asthma is a common chronic inflammatory disease affecting more than million people worldwide and could develop at any age; however, the first asthma symptoms mostly appear in the childhood. Episodes of bronchial hyper-responsiveness and reversible airway obstruction are the characteristic hallmarks of asthma. The main causes of asthma are not known; however, several factors trigger the pathogenesis cascade of asthma, which include environmental triggers such as pollutants, tobacco smoking, allergens, viral and…

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