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Research Article: Resolvin D Attenuates Inflammation and Pelvic Pain Associated with EAP by Inhibiting Oxidative Stress and NLRP Inflammasome Activation via the Nrf/HO- Pathway

Date Published: 2023-08-08

Abstract:
Chronic prostatitis, a very common disease of the genitourinary system, affected approximately –% of men in their lifetime.– Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) is the most common type, accounting for more than % of all cases of chronic prostatitis among males under years of age. CP/CPPS is a poorly understood syndrome characterized by perineal or pelvic pain, urinary irritation, psychological issues, and sexual dysfunction without infection, and it negatively affects sperm and quality of life.– As the etiology of CP/CPPS is still not well understood, available therapeutic options including alpha blockers, anti-inflammatory drugs, physiotherapy, and neuroleptics are far from satisfactory to either patients or physicians., Therefore, a new treatment for CP/CPPS and a better understanding of its pathogenesis are urgently needed.

Introduction:
Chronic prostatitis, a very common disease of the genitourinary system, affected approximately –% of men in their lifetime. – Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) is the most common type, accounting for more than % of all cases of chronic prostatitis among males under years of age. CP/CPPS is a poorly understood syndrome characterized by perineal or pelvic pain, urinary irritation, psychological issues, and sexual dysfunction without infection, and it negatively affects sperm and quality…

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