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Research Article: Causes of Drug-Induced Severe Cutaneous Adverse Reaction Epidermal Necrolysis (EN): An Analysis Using FDA Adverse Event Reporting System (FAERS) Database

Date Published: 2023-08-16

Introduction:
Epidermal necrolysis (EN), a severe cutaneous adverse reaction, comprises two subtypes, namely toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS). The condition is characterized by the loss of the epidermis, resulting from extensive apoptosis and/or necroptosis of keratinocytes. SJS and TEN are part of a spectrum of diseases, with SJS representing a milder form of epidermolysis involving an area of less than % of the body surface area. Conversely, TEN is a more severe form, involving an area of…

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