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Research Article: The Burden of Sickle Cell Disease on Children and Their Caregivers: Caregiver Reports of Children’s Health-Related Quality of Life and School Experiences, Caregiver Burden, and Their Association with Frequency of Vaso-Occlusive Crises

Date Published: 2023-11-28

Abstract:
Sickle cell disease (SCD) is a group of genetic blood disorders that cause a mutant form of hemoglobin that is less soluble than normal hemoglobin and is prone to polymerization upon deoxygenation., The polymerization of hemoglobin causes deformation of red blood cells, giving them a sickle shape and causing chronic hemolysis, anemia, and vaso-occlusion.,

Introduction:
Sickle cell disease (SCD) is a group of genetic blood disorders that cause a mutant form of hemoglobin that is less soluble than normal hemoglobin and is prone to polymerization upon deoxygenation. , The polymerization of hemoglobin causes deformation of red blood cells, giving them a sickle shape and causing chronic hemolysis, anemia, and vaso-occlusion. ,

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