Research Article: Flow Cytometric Enumeration of Peripheral Blood CD+ Cells Predicts Bone Marrow Pathology in Patients with Less Than % Blasts by Manual Count
Introduction:
Although numerous advances in characterization of myeloid neoplasms largely derived from gene expression analysis and next generation sequencing are now available, the percentage of myeloblasts in the bone marrow and peripheral blood remains the most important parameter in diagnosing acute myeloid leukemia, myelodysplastic syndrome, and myeloproliferative neoplasms. When myeloblasts are detected by microscopic examination of the peripheral blood smear, a subsequent bone marrow study is typically necessary to…
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