Research Article: The Interaction of LAMA and Duration of Illness Affects the Thickness of the Right Transverse Temporal Gyrus in Major Depressive Disorder
Abstract:
Major depressive disorder (MDD), a heritable brain disorder, commonly begins in youth and continues throughout one’s life. According to World Health Organization, the lifetime prevalence of depression is around .%, which has caused an enormous burden. The pathogenesis of MDD is still unclear, and several brain structure alterations. Two meta-analyses found that the hippocampal volume, especially the cortical thickness of the orbitofrontal cortex and anterior cingulate cortex in patients with depression, were smaller than those in normal people., In addition, the disease course of MDD might affect these brain deficits. Several longitudinal studies of depression have found that gray matter loss is associated with the disease course of depression.,
Introduction:
Major depressive disorder (MDD), a heritable brain disorder, commonly begins in youth and continues throughout one’s life. According to World Health Organization, the lifetime prevalence of depression is around .%, which has caused an enormous burden. The pathogenesis of MDD is still unclear, and several brain structure alterations. Two meta-analyses found that the hippocampal volume, especially the cortical thickness of the orbitofrontal cortex and anterior cingulate cortex in patients with depression, were…
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