Research Article: Use of Ceftazidime-Avibactam for Suspected or Confirmed Carbapenem-Resistant Organisms in Children: A Retrospective Study
Abstract:
Multidrug resistance, caused mainly by excessive use of antibiotics, is one of the greatest challenges to public health worldwide. The search for new antimicrobial strategies is urgent. In children, the incidence of infections caused by carbapenem-resistant Gram-negative bacteria is increasing. A study on carbapenem resistance prevalence in US children reported that, from January to July , the frequency of carbapenem resistance increased from % in – to .% in – among Enterobacterales species, from .% in to % in among Pseudomonas aeruginosa species, and from .% in to .% in among Acinetobacter Baumannii species. Available pediatric case series suggest that infections due to these organisms are associated with significant mortality, ranging from % to %.– In pediatric cancer patients with bloodstream infections, the mortality rate is as high as %. Despite widespread attention paid to carbapenem-resistant threats, antibiotic treatment of these infections in children remains challenging, given the limited clinical data on active drugs.
Introduction:
Multidrug resistance, caused mainly by excessive use of antibiotics, is one of the greatest challenges to public health worldwide. The search for new antimicrobial strategies is urgent. In children, the incidence of infections caused by carbapenem-resistant Gram-negative bacteria is increasing. A study on carbapenem resistance prevalence in US children reported that, from January to July , the frequency of carbapenem resistance increased from % in – to .% in – among Enterobacterales species, from .% in to % in…
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