Research Article: Prophylactic Treatment of Intestinal Ischemia-Reperfusion Injury Reduces Mucosal Damage and Improves Intestinal Absorption
Introduction:
Acute mesenteric ischemia (AMI) is a medical condition defined as an abrupt decrease or interruption in intestinal blood flow, resulting in an inadequate supply of oxygen and nutrients leading to intestinal infarction. Under inadequate oxygen supply to the enterocyte, xanthine dehydrogenase is converted into xanthine oxidase, an enzyme which has a high formation capacity of reactive oxygen species (ROS). During reperfusion, ROS are released into the bloodstream and distributed throughout the organism, not only…
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