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Research Article: Knowledge Mapping and Research Hotspots of Generalized Pustular Psoriasis: A Bibliometric Analysis from to

Date Published: 2023-12-20

Abstract:
Psoriasis is a chronic-inflammatory cutaneous disease that exhibits diverse clinical manifestations. The most common form of psoriasis, known as plaque psoriasis, primarily arises from adaptive immune system abnormalities. Generalized pustular psoriasis (GPP), a more severe and infrequent subtype of psoriasis that may be life-threatening, is associated with excessive activation of the innate immune system. GPP is characterized by widespread eruptions of sterile, macroscopic pustules that manifest with or without signs of systemic inflammation., The management of GPP poses significant challenges, mostly due to the difference in pathogeneses compared to plaque psoriasis. It is now understood that GPP has an indirect impact on the economy through exacerbation of work productivity impairment. However, a lack of global consensus on the clinical criteria for GPP diagnosis and treatment goal establishment persists. However, no consensus has been reached regarding the clinical criteria for diagnosing GPP and establishing treatment goals. Accordingly, a comprehensive exploration of GPP is crucial, as it will facilitate the development of novel concepts for clinical prevention and treatment approaches.

Introduction:
Psoriasis is a chronic-inflammatory cutaneous disease that exhibits diverse clinical manifestations. The most common form of psoriasis, known as plaque psoriasis, primarily arises from adaptive immune system abnormalities. Generalized pustular psoriasis (GPP), a more severe and infrequent subtype of psoriasis that may be life-threatening, is associated with excessive activation of the innate immune system. GPP is characterized by widespread eruptions of sterile, macroscopic pustules that manifest with or without…

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