Research Article: Association Between CTSK Gene Polymorphisms and Response to Alendronate Treatment in Postmenopausal Chinese Women with Low Bone Mineral Density
Introduction:
Osteoporosis is a complex disease characterized by reduction of bone mass and strength, destruction of bone microstructure, increase in bone brittleness and susceptibility to fractures. It is generally believed to be caused by genetic and environmental factors. It tends to occur in postmenopausal and older women. A minor trauma or daily activities can lead to fracture of hip, vertebral body, distal radius and proximal humerus, which is called fragility fracture. The hip fracture is the most important cause of…
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