Research Article: Chonggu Granules Improve Cartilage Matrix Metabolism in Knee Osteoarthritis via the miR-a-p/Wnt/?-Catenin Pathway
Introduction:
Knee osteoarthritis (KOA) is the most common degenerative joint disease that causes significant physical disability among the middle-aged and elderly population, which brings certain economic burden to both family members and society. The major pathological hallmarks of KOA include subchondral sclerosis, synovial inflammation, and osteophyte hyperplasia, etc., resulting in corresponding clinical manifestations such as swelling, pain, rigidity, and limited joint activity in patients. KOA has a multifactorial…
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