Research Article: Sonosensitizer Nanoplatforms Augmented Sonodynamic Therapy-Sensitizing Shikonin-Induced Necroptosis Against Hepatocellular Carcinoma
Abstract:
Primary liver cancer ranks third in tumor incidence., Due to the lack of specific clinical manifestations, primary liver cancer is already at the advanced stage at the time of diagnosis, resulting in poor prognosis of the disease., Hepatocellular carcinoma (HCC) is the main etiologic type of primary liver carcinoma., The current clinical targeted therapeutics for advanced HCC, such as sorafenib, face drug resistance after several months of treatment, which reduces the therapeutic efficacy., Thus, it is urgent to explore ways to improve drug resistance and the therapeutic effect of liver cancer, which is an essential research direction for HCC treatment.
Introduction:
Primary liver cancer ranks third in tumor incidence. , Due to the lack of specific clinical manifestations, primary liver cancer is already at the advanced stage at the time of diagnosis, resulting in poor prognosis of the disease. , Hepatocellular carcinoma (HCC) is the main etiologic type of primary liver carcinoma. , The current clinical targeted therapeutics for advanced HCC, such as sorafenib, face drug resistance after several months of treatment, which reduces the therapeutic efficacy. , Thus, it is urgent…
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