Research Article: Nano-Emulsion Based Gel for Topical Delivery of an Anti-Inflammatory Drug: In vitro and in vivo Evaluation
Introduction:
Arthritic disease is one of the most common disorders and a main cause of joint dysfunction and disability in the elderly patient. , The most predominant type of arthritis is rheumatoid arthritis, which is caused by the activation of pro-inflammatory mediators such as IL-? and TNF-? which is characterized by peripheral joint pain, swelling, and stiffness. Rheumatoid arthritis treatment is depending mainly on the use of analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, monoclonal…
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