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Research Article: Distribution Patterns of Pathogens Causing Lower Respiratory Tract Infection Based on Metagenomic Next-Generation Sequencing

Date Published: 2023-10-10

Introduction:
Lower respiratory tract infection (LRTI) remains one of the leading causes of death worldwide. Several well-known pathogens, including Streptococcus pneumoniae, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida, Herpesvirus , and others, have been identified as significant causes of infection. Nonetheless, nearly half of the cases still have an undetermined etiology, , despite the extensive application of clinical microbiology tests. In certain scenarios, LRTI can progress to severe pneumonia, multiple organ…

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