Research Article: Enhanced Osteogenic Activity and Bone Repair Ability of PLGA/MBG Scaffolds Doped with ZIF- Nanoparticles Loaded with BMP-
Abstract:
Bone defects caused by trauma, infection, tumors, and fracture nonunion are common in orthopedic clinics. Autologous or allogeneic bone grafts are usually used to restore the integrity of bone defects, but bone grafting is often restricted by limited tissue to harvest, reduced bioactivity, donor site morbidity, pathogen transmission risk and immune rejection. Bone tissue engineering (BTE) scaffolds involve the use of biomaterials and growth factors that enhance cell differentiation, improve osteogenic activity and promote bone repair.,
Introduction:
Bone defects caused by trauma, infection, tumors, and fracture nonunion are common in orthopedic clinics. Autologous or allogeneic bone grafts are usually used to restore the integrity of bone defects, but bone grafting is often restricted by limited tissue to harvest, reduced bioactivity, donor site morbidity, pathogen transmission risk and immune rejection. Bone tissue engineering (BTE) scaffolds involve the use of biomaterials and growth factors that enhance cell differentiation, improve osteogenic activity and…
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