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Research Article: Effective Attenuation of Arteriosclerosis Following Lymphatic-Targeted Delivery of Hyaluronic Acid-Decorated Rapamycin Liposomes

Date Published: 2023-08-02

Abstract:
Cardiovascular disease remains a major cause of morbidity and mortality worldwide. Pathologically, the dominating etiology involves atherosclerosis, a chronic inflammatory disease characterized by the formation of lipid plaques in the intima of arteries, which can lead to life-threatening cardiovascular diseases such as coronary heart disease, myocardial infarction, stroke, and so on., Immunosuppression therapy represents an attractive option. In addition, there is increasing evidence that autophagy occurs in advanced atherosclerotic plaques. Selectively activating autophagic death of macrophages could stabilize the fragile and ruptured lesions., These findings strongly indicate that multi-active therapeutic agents are favorable for the inhibition of atherosclerosis progression.

Introduction:
Cardiovascular disease remains a major cause of morbidity and mortality worldwide. Pathologically, the dominating etiology involves atherosclerosis, a chronic inflammatory disease characterized by the formation of lipid plaques in the intima of arteries, which can lead to life-threatening cardiovascular diseases such as coronary heart disease, myocardial infarction, stroke, and so on. , Immunosuppression therapy represents an attractive option. In addition, there is increasing evidence that autophagy occurs in…

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