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Research Article: Establishment of a Nomogram Based on Inflammatory Response-Related Methylation Sites in Intraoperative Visceral Adipose Tissue to Predict EWL% at One Year After LSG

Date Published: 2023-05-08

Abstract:
Recently, the number of people with excess body weight has surpassed billion, accounting for % of the global population. Obesity increases the incidence of other diseases, such as type  diabetes mellitus (TDM), coronary heart disease, stroke, hypertension, and cancer. In individuals with overweight and obesity, metabolic disease and organ tissue complications are mechanistically related to chronic low-grade inflammation of adipose tissue., Chronic inflammation in adipose tissue is linked to dysfunctional adipocytes that secret inflammatory adipokines and immune cells that produce cytokines and chemokines. Chronic inflammation-mediated tissue damage has been observed in many organs, including the heart, pancreas, liver, lungs, brain, and intestines. Currently, an increasing number of studies attempt to investigate the mechanisms of obesity from the perspective of inflammation.

Introduction:
Recently, the number of people with excess body weight has surpassed billion, accounting for % of the global population. Obesity increases the incidence of other diseases, such as type diabetes mellitus (TDM), coronary heart disease, stroke, hypertension, and cancer. In individuals with overweight and obesity, metabolic disease and organ tissue complications are mechanistically related to chronic low-grade inflammation of adipose tissue. , Chronic inflammation in adipose tissue is linked to dysfunctional…

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