Research Article: The Burden of Inappropriate Prescriptions and Predictors for Hospitalized Patients with Liver Cirrhosis in Ethiopia

Abstract:
The liver is an organ in which the majority of medications are primarily metabolized and excreted. Whereas Cirrhosis, which results from a variety of chronic liver illnesses, is a gradually deteriorating liver illness marked by scarring and the change of healthy liver morphology into structurally aberrant nodules.– Pathophysiological alterations in liver cirrhosis impact how external agents, including medications, are eliminated, leading to drug-induced liver damage, which is defined as a short-term or ongoing liver damage brought on by medications or components of herbs.– The main reasons of disability of the health-care system in developing nations are improper medication usage and inappropriate prescribing. Numerous medications are known to induce liver damage or perhaps have been suspected of doing so. More than medications have been linked to aggressive hepatic failure; more than medications have been shown to be associated with liver damage; and % of all adverse drug reactions have hepatotoxic consequences., However, it is been noticed that cirrhotic individuals frequently receive prescriptions for medications that are more likely to harm them. Nearly % of cirrhosis patients experience possibly avoidable adverse drug reactions, and % of all those reactions have detrimental impacts on the functioning of the liver., Likewise, improper prescription in patients with cirrhosis results in an increase in the rate of adverse drug reactions, hospitalizations and inpatient stays, more over due to the disruption of drug metabolism, polypharmacy is a primary cause of adverse drug reactions, which are especially harmful in hepatic diseases. Thus, when considering the prescription of hepatotoxic drugs to patients with cirrhosis, a safe medication prescription has more relevance,,, The existence of cirrhosis-related complications has a dual effect: first, it raises the cost of treatment, and second, it makes it more difficult to prescribe medications to cirrhotic patients so it is important to give attention to prescription of medication to treat both the underlying cause and any related complications., Additionally, it is crucial to adjust dosages in cirrhotic patients; reduced doses or fewer frequent administrations are usually recommended to avoid excessive drug deposition and active drug metabolite buildup that could result in severe adverse effects., Drug formulary references provide advice on which medications should be used cautiously, or not at all, in patients with cirrhosis. According to reports, the estimated inpatient mortality of patients with cirrhosis in Ethiopia is high; it causes deaths and hospital admissions in approximately % and % of cirrhotic patients., Since patients with cirrhosis require a complex therapy plan, it necessitates regular reviews of medication utilization. However, a search of the literature reveals that there is no data on medication prescription patterns among cirrhosis patients in Ethiopia. The aim of this study was to assess the burden of inappropriate medication prescriptions and its predictors among hospitalized cirrhotic patients at Felege-Hiwot Specialized and Comprehensive Referral Hospital.

Introduction:
The liver is an organ in which the majority of medications are primarily metabolized and excreted. Whereas Cirrhosis, which results from a variety of chronic liver illnesses, is a gradually deteriorating liver illness marked by scarring and the change of healthy liver morphology into structurally aberrant nodules. – Pathophysiological alterations in liver cirrhosis impact how external agents, including medications, are eliminated, leading to drug-induced liver damage, which is defined as a short-term or ongoing…

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