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Research Article: Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-?/Smad/ Signaling Pathway in Spontaneously Hypertensive Rats

Date Published: 2023-09-07

Introduction:
Hypertension renal disease (HRD) is a kind of chronic kidney disease (CKD) in which the main etiology is primary hypertension. It affects a large number of people worldwide and has become a severe public healthcare problem. As the disease progresses, it will cause functional and structural damage to the kidney, then develop into end-stage renal disease (ERSD) and eventually lead to death The renal injury caused by hypertensive nephropathy is characterized by renal tubular injury, renal interstitial fibrosis, and…

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