Research Article: OCE-, a Selective Va Partial Agonist, Reduces Portal Pressure in Rat Models of Portal Hypertension
Introduction:
Decompensated cirrhosis and its serious hemodynamic complications are a critical area unmet need for patients. Systemic hemodynamic complications are typical of portal hypertension (PHT) and cirrhosis. – PHT produces alterations in cardiovascular function and tone, with splanchnic arterial vasodilation, reduced systemic vascular resistance, and lower effective arterial blood volume along with arterial pressure reductions. Effective hypovolemia, low perfusion pressure, and reduced glomerular filtration rate can…
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