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Research Article: Untargeted Plasma Lipidomics Reveal Perturbed Metabolites of Glycerophospholipids, and Sphingolipids in Moderate-to-Severe Acne

Date Published: 2023-08-11

Abstract:
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit and affects skin sites with a high density of sebaceous glands, such as face, back, and chest., It affects approximately % of world’s population aged to years. Typical acne lesions include open and closed comedones, inflammatory papules, pustules, and nodules. AV is a multifactorial disease, and its precise pathogenesis remains unknown. Four factors are believed to play a pivotal role in the formation of acne lesions, including excessive sebum, disturbed keratinization within the follicle, altered bacterial colonization with Cutibacterium acnes, and inflammation.–

Introduction:
Acne vulgaris (AV) is a common inflammatory disorder involving the pilosebaceous unit and affects skin sites with a high density of sebaceous glands, such as face, back, and chest. , It affects approximately % of world’s population aged to years. Typical acne lesions include open and closed comedones, inflammatory papules, pustules, and nodules. AV is a multifactorial disease, and its precise pathogenesis remains unknown. Four factors are believed to play a pivotal role in the formation of acne lesions, including…

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