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Research Article: Characterization of Epidermal Function in Individuals with Primary Cutaneous Amyloidosis

Date Published: 2023-11-06

Introduction:
Primary cutaneous amyloidosis (PCA) is a persistent pruritic dermatosis defined by the localized amyloid deposition in the papillary dermis. Lichenoid amyloidosis (LA) and macular amyloidosis (MA) emerge as its two predominant types. The differentiation between LA and MA rests largely on patients’ clinical and pathological manifestations. LA is mainly identified by brown, rice-sized papules on the legs, densely arranged yet separate. Its pathological characteristics include hyperkeratosis, hyperacanthosis, and…

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