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Research Article: Cigarette Smoking Contributes to Th/Th Cell Dysfunction via the Cytokine Milieu in Chronic Obstructive Pulmonary Disease

Date Published: 2023-09-12

Abstract:
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and is characterized by local and systemic inflammation. In addition to innate immunity, an increasing number of studies suggest that that adaptive immune responses play key roles in the pathogenesis of COPD, as COPD is typically characterized by the propagation of autoreactive T cells and B cells., These pathogenic lymphocyte cells exert a variety of functions by releasing various mediators and recruiting and activating other immune and parenchymal effector cells. Tobacco Smoke skews immune responses to promote the development of COPD, and smoking cessation can change the natural history of COPD.–

Introduction:
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and is characterized by local and systemic inflammation. In addition to innate immunity, an increasing number of studies suggest that that adaptive immune responses play key roles in the pathogenesis of COPD, as COPD is typically characterized by the propagation of autoreactive T cells and B cells. , These pathogenic lymphocyte cells exert a variety of functions by releasing various mediators and recruiting and activating…

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