Research Article: Gene Expression of Human Beta-Defensin- and Cathelicidin in the Skin of Leprosy Patients, Household Contacts, and Healthy Individuals from Indonesia
Abstract:
Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae (M. leprae), and M. lepromatous which mainly attacks the skin, peripheral nerves, mucosa of the upper respiratory tract, eyes, muscles, bones, and testis.– Indonesia is the third-highest country in the world after India and Brazil for new leprosy cases.– Household contacts are people who have been in close contact with leprosy patients and are – times more likely to suffer from leprosy than non-contacts or general population.,, Frequent exposure of contacts to M. leprae results in a persistently active innate immune system. The World Health Organization (WHO) classifies leprosy into two types based on cardinal signs: paucibacillary (PB) and multibacillary (MB) leprosy.,,
Introduction:
Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae ( M. leprae ), and M. lepromatous which mainly attacks the skin, peripheral nerves, mucosa of the upper respiratory tract, eyes, muscles, bones, and testis. – Indonesia is the third-highest country in the world after India and Brazil for new leprosy cases. – Household contacts are people who have been in close contact with leprosy patients and are – times more likely to suffer from leprosy than non-contacts or general population.…
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