Research Article: Diagnostic Performance of Metagenomic Next-Generation Sequencing in Central Nervous System Cryptococcosis Using Cerebrospinal Fluid
Introduction:
Central nervous system (CNS) cryptococcosis is an invasive fungal infection caused by Cryptococcus spp. Although the infection is preventable and treatable, its morbidity and mortality rates are still high. Global cryptococcal meningitis accounts for % of acquired immune deficiency syndrome-related deaths, with an estimated , deaths annually. In the Asia and Pacific region, approximate , HIV-infected adults developed cryptococcal meningitis, and , cryptococcal-related deaths occurred annually. Consequently,…
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