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Research Article: Interactions of Fibroblast Subtypes Influence Osteoclastogenesis and Alveolar Bone Destruction in Periodontitis

Date Published: 2023-07-25

Abstract:
Both gingivitis and periodontitis are microbial-initiated inflammation in periodontal tissues, exhibiting bleeding on probing (BOP) or increased probing depth (PD). Most gingivitis is confined to gingival tissues without destroying tooth-supporting structures, but some gingivitis further develops into periodontitis, leading to clinical attachment loss (CAL) and alveolar bone destruction. However, it is unclear why some gingivitis readily develops into periodontitis and others remain stable for several years even though the patients’ general health is similar.,

Introduction:
Both gingivitis and periodontitis are microbial-initiated inflammation in periodontal tissues, exhibiting bleeding on probing (BOP) or increased probing depth (PD). Most gingivitis is confined to gingival tissues without destroying tooth-supporting structures, but some gingivitis further develops into periodontitis, leading to clinical attachment loss (CAL) and alveolar bone destruction. However, it is unclear why some gingivitis readily develops into periodontitis and others remain stable for several years even…

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