Research Article: Arginine Biosynthesis Pathway Found to Play a Key Role in the Neuroprotective Effect of Liu-Wei-Luo-Bi (LWLB) Granules in Diabetic db/db Mice with Peripheral Neuropathy Using an Untargeted Metabolomics Strategy
Introduction:
Diabetic peripheral neuropathy (DPN) is a major cause of reduced quality of life and has an important impact on patients because of pain, sensory loss, gait instability, fall-related injury, and foot ulceration and amputation. – Currently, intensive glycemic control and symptomatic treatment are the only therapies available for DPN. – However, recent studies have shown that glycemic control and symptomatic treatment were not suitable as a long-term treatment because of the possibility of digestive and nervous…
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