Research Article: Hollow Hydroxyapatite Microspheres Loaded with rhCXCL to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects
Introduction:
Large refractory bones with poor blood circulation, large scope or weakened osteogenic capacity have been a great challenge for orthopaedic surgeons. Multiple surgeries are required, resulting in poor efficacy and even amputation, which imposes a substantial economic and social burden on patients. Currently, autologous bone graft with vascular pedicle remains the gold standard for clinical bone repair. However, this operation has several disadvantages, limited quantities available, large surgical wounds, strict…
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